Dupuytren Contracture Causes and Risk Factors

Dupuytrens contracture is a painless thickening and tightening (contracture) of tissue beneath the skin on the palm of the hand and fingers.

Dupuytren’s contracture is a condition of the hands and fingers. It is sometimes called Dupuytren’s disease because not everyone with this condition develops contractures.

At first, there is a thickening of some tissues under the skin in the palm. If the disease progresses you may develop a contracture of one or more fingers. When you have a contracture, affected fingers bend (contract) towards the palm and you cannot straighten them fully.

Typically, the ring finger is usually affected first. Then the little finger, and then the middle finger. It takes months or years for the condition to develop and progress to a contracture.

Dupuytren’s contracture is not usually painful. The main problem is that if one or more contractures develop, you cannot use the affected fingers properly. The extent of a contracture varies greatly from mild to severe. Sometimes just one hand is affected. Commonly, it affects both hands.

Some people with Dupuytren’s contracture have some thickened tissue under the skin in other parts of their body. For example, a thickening on the knuckles, on the soles of the feet, or on the penis.

The picture shows a severe contracture of the little finger and a mild contracture of the ring finger. You can also see some thickening of the tissues under the skin in the palm.


The cause is unknown. Family history of Dupuytrens contracture makes you more likely to develop this condition. It does not seem to be caused by occupation or from trauma.

The condition is more common after age 40. Men are affected more often than women. Risk factors are alcoholism, diabetes, and smoking.

The tissue called the connective tissue in the affected palm becomes thick and abnormal. This is the tissue just under the skin but above the tendons. This forms into bands of thick tissue which, when it gets worse, pulls the fingers towards the palm.

The abnormal tissue that forms is similar to scar tissue that forms following a wound.

The reason why this tissue becomes thickened is not known. There seems to be a genetic factor as it has a tendency to run in some families and it is more common in some countries – mainly northern European.

It is more common in people with diabetes, epilepsy, and alcohol dependence – but most people with Dupuytren’s contracture do not have any of these other conditions.

In some cases it is thought that an injury to the hand may trigger the condition to start in someone who is genetically prone to develop the condition.

However, in most people with Dupuytren’s contracture, there is no known cause or associated illness or injury. It is not due to your type of job, vibrating tools, manual work, or other working environments.


One or both hands may be affected. The ring finger is affected most often, followed by the little, middle, and index fingers.

A small, painless nodule or lump develops in the tissue below the skin on the palm side of the hand. Over time, it thickens into a cord-like band.

It becomes difficult to extend or straighten the fingers. In severe cases, straightening them is impossible.

Exams and Tests

The doctor will examine your hands. Diagnosis can usually be made from the telltale signs of Dupuytrens contracture. Other tests are rarely needed.


Your doctor may recommend exercises, warm water baths, or splints.

Surgery may be done to release the contracture. Normal movement of the fingers is usually restored by surgery followed by physical therapy exercises for the hand.

A newer treatment involves injecting a substance called collagenase into the scarred or fibrous tissue. Three injections are needed. You may have side effects such as swelling, pain, and itching. A more rare but severe side effect is rupture of the tendon.

Many people with Dupuytren’s contracture do not need any treatment. In many cases the condition remains mild and causes little interference with the use of the hand. There may be just thickened tissue, or thickened tissue with a mild contracture.

In these situations no treatment is usually advised. Also, in about 1 in 10 cases, the condition improves without any treatment. However, the condition does tend to worsen over time in some cases. The need for treatment can be reviewed from time to time.

As a general rule, your GP will refer you to a hand specialist for assessment if you are not able to place your hand flat on a table top or if your hand function is significantly affected. The specialist may consider nonsurgical or surgical options for treatment.

The aims of treatment are to restore hand function and prevent progression of the disease.

Non-surgical treatment options
Splinting or stretching and local steroid injections are not recommended.

Radiation therapy

Radiation therapy for Dupuytren’s contracture consists of having several low doses of X-rays to the affected hand. The theory is that this will soften the abnormal tissue, which will then stop or slow down the progression of the disease. There is some uncertainty about how well this treatment works.

However, some research studies suggest that there is a reasonable chance of this treatment working well. Some people develop side-effects following treatment, such as dry skin on the hands. Also, as with any type of radiation therapy, there is a theoretical risk that cancer might develop in the treated tissue in the long term (although this is thought to be very unlikely).

Your specialist will be able to advise on the pros and cons of trying this treatment.

Surgical treatments for Dupuytren’s contracture

As a general rule, a specialist may recommend a treatment to straighten out the affected finger or fingers if:

There is a contracture of 30-40° or more at a joint between the palm and a finger (a metacarpophalangeal (MCP) joint).

There is a contracture of 10-20° or more between one of the small joints in a finger. Surgery ‘earlier than later’ may be recommended if the bend (contracture) is affecting the first joint within the finger itself, as it is more difficult to correct this with the passing of time.
There are three main types of surgical procedure:

Open fasciotomy

Fasciotomy simply means cutting the thickened tissue. (Another word for the thickened tissue is ‘fascia’.) Open fasciotomy means that to get to the thickened tissue, the overlying skin is cut open. This allows the surgeon to see the thickened tissue, and then to cut it. The skin is then stitched back together. It is a relatively minor procedure which can be done under local anaesthetic as a day case.

Needle fasciotomy
This is sometimes called needle aponeurotomy or closed fasciotomy. What happens is that the specialist pushes a fine needle through the skin over the contracture. He or she then uses the sharp bevel of the needle to cut the thickened tissue under the skin. In effect, the needle acts like a saw as the specialist moves the needle to and fro to saw through the thickened tissue. The procedure is done under local anaesthetic and can be done in an outpatient clinic.

Needle fasciotomy has received quite a bit of press coverage, as it sounds like an easy, quick procedure with minimal intervention. However, it is not always suitable. This is because:

  • It is mainly suitable where the contracture is away from important nerves in the hand.
  • It tends not to be suitable for severe contractures.
  • There is a good chance it will not be of benefit in the long term. The contracture returns in about half of cases within 3-5 years following this procedure. (But, if it does return, the procedure may be able to be repeated.)
  • As the specialist cannot see the end of the needle once it is inserted, there is a risk of damage to nearby tendons, blood vessels and nerves, which can cause long-term problems.
  • Needle fasciotomy tends to be mainly suitable for older patients who are unsuitable for more definitive curative surgery, and in some cases where the contracture is in certain sites. Your specialist will advise if it is an option for you.

Open fasciectomy

This means removing the abnormal thickened tissue. This is a more extensive hand operation. However, it gives the best chance of a long-term cure. It is the most commonly done procedure to treat Dupuytren’s contracture.

Remember, all operations (surgical procedures) carry a risk. There is a small risk of damage to nearby tendons, blood vessels and nerves during any of the above procedures, and of infection developing in the hand.

Outlook (Prognosis)

The disorder progresses at an unpredictable rate. Surgical treatment can usually restore normal movement to the fingers. The disease can recur following surgery in up to half of cases within 10 years.

Possible Complications

Worsening of the contracture may result in deformity and loss of function of the hand.

There is a risk of injury to blood vessels and nerves during surgery.

When to Contact a Medical Professional

Call your health care provider if you have symptoms of this disorder.


Awareness of risk factors may allow early detection and treatment.

Source & More Info: Medline and Patient.co.uk



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