Superior Vena Cava Syndrome Treatment

The superior vena cava is a large vein located in the upper chest, which collects blood from the head and arms and delivers it back to the right atrium of the heart.

If this vein is compressed by outside structures, or if a thrombus or clot develops within it, return blood flow to the heart is impeded.

When blood flow to the heart is restricted, the increased pressure in the veins of the face and arms causes edema (fluid buildup) in these areas. This condition is referred to as superior vena cava syndrome.

Because the superior vena cava, like all veins, has a thin wall (there are no muscles in the walls of a vein as compared to the walls of an artery), and because there is little pressure inside the vein, it can be easily compressed by outside structures.

The superior vena cava lies next to the upper lobe of the right lung and within the mediastinum [the space that contains the central structures of the chest: the heart, the trachea, the esophagus and the great vessels (aorta, vena cava)].

Abnormalities within any of these structures can cause the compression.

Symptoms

Relieving side effects €”also called symptom management, palliative care, or supportive care—is an important part of cancer care and treatment.

Talk with your health care team about any symptoms you experience, including any new symptoms or a change in symptoms.

Symptoms usually develop slowly and include difficulty breathing or shortness of breath, coughing, and swelling of the face, neck, upper body, and arms.

Rarely, patients may experience hoarseness, chest pain, difficulty swallowing, and hemoptysis (coughing up blood from the lungs and throat).

Rare, severe symptoms include swelling of the veins in the chest and neck, fluid collection in the arms and face, and an increased rate of breathing.

In severe instances, a person’s skin may turn blue due to cyanosis (lack of oxygen).

Also, in rare instances, the person may experience paralysis (loss of the ability to move) of the vocal cords or Horner’s syndrome, characterized by a constricted pupil, sagging eyelid, and absence of sweat on one side of the face.

SVCS may develop quickly, completely blocking the trachea (airway). When this occurs, a ventilator may be needed to help the patient breathe until the blockage can be treated.

More commonly, if the blockage develops slowly, other veins may enlarge to carry extra blood, and symptoms may be milder.

Because SVCS can cause serious breathing problems, it is considered an emergency. If you experience any of these symptoms, contact your doctor immediately.

Although SVCS is serious and has symptoms that may be frightening, it is treated successfully in most people.

Causes

A tumor growing inside the chest may press on the superior vena cava, which drains into the right atrium (upper chamber) of the heart.

The types of cancer that most commonly cause SVCS include lung cancer, non-Hodgkin lymphoma, and cancers that spread to the chest.

Sometimes a tumor originally located outside the superior vena cava may grow into the vein, causing a blockage.

Because the superior vena cava is surrounded by lymph nodes (tiny, bean-shaped organs that fight infection), any cancer that spreads to these lymph nodes and causes them to enlarge can also cause SVCS. Enlarged lymph nodes compress the vein, which slows blood flow and may result in complete blockage.

A less common cause of SVCS is a thrombosis (blood clot) in the vein, caused by an intravenous catheter (a flexible tube placed in a vein to take out or put in fluids) or a pacemaker wire.

Diagnosis

Tests that may be done to diagnose SVCS include a chest x-ray, computerized tomography (CT) scan, or magnetic resonance imaging (MRI), venography (an x-ray done after injecting a special dye into the patient’s vein), and ultrasound.

Management

If symptoms are mild, the trachea is not blocked, and blood is flowing well through other veins in the chest, treatment may not begin until a clear diagnosis is made, or treatment may not be needed.

In most cases, SVCS is managed by treating the cancer that is causing the blockage with chemotherapy or radiation therapy.

Other short-term treatments to reduce symptoms include raising the patient’s head, giving corticosteroids (medications used to reduce swelling), or using diuretics (medications that eliminate excess fluid from the body by increasing urination).

Less often, SVCS may be treated with thrombolysis (treatment to break up a blot clot in the vein), stent placement (the insertion of a tube-like device into the blocked area of the vein to allow blood to pass through), or surgery to bypass a blockage.

What is the prognosis for superior vena cava syndrome?

The outcome and prognosis is dependent upon the underlying cause of the superior vena cava syndrome

Source & More Info: Cancer.net and Medicine Net

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